NAF Methotrexate/Misoprostol Recommendations/Page 6 of 7
SELECTED STUDIES ON REGIMENS WITH METHOTREXATE/MISOPROSTOL:
Carbonell JLL, Varela L, Velazco A, Cabezas E, Fernandez C, Sanchez C. Oral methotrexate
and vaginal misoprostol for early abortion. Contraception 1998;57:83-8.
Carbonell JLL, Varela L, Velazco A, Tanda R, Sanchez C. 25 mg or 50 mg of oral methotrexate
followed by vaginal misoprostol 7 days after for early abortion. Gynecol Obstet Invest
1999;47:182-7.
Carbonell JLL, Velazco A, Varela L. Cabezas E, Fernandez C, Sanchez C. Misoprostol 3,4, or 5
days after methotrexate for early abortion: a randomized trial. Contraception 1997;56:169-74.
Creinin MD. Change in serum B-hCG after abortion with methotrexate and misoprostol. Am J
Obstet Gynecol 1996;174:776.
Creinin MD. Methotrexate for abortion at ≤42 days gestation. Contraception 1993;48:519-25.
Creinin MD. Oral methotrexate and vaginal misoprostol for early abortion. Contraception
1996;54:15-8.
Creinin MD. Medical abortion with methotrexate 75 mg intramuscularly and vaginal
misoprostol. Contraception 1997;56:367-71.
Creinin MD, Burke AE. Methotrexate and misoprostol for early abortion: A multicenter trial.
Acceptability. Contraception 1996;54:19-22.
Creinin MD, Carbonell JLL, Schwartz JL, Varela L, Tanda R. A randomized trial of the effect
of moistening misoprostol before vaginal administration when used with methotrexate for
abortion. Contraception 1999;59:11-6.
Creinin MD, Darney PD. Methotrexate and misoprostol for early abortion. Contraception
1993;48:339-48.
Creinin MD, Edwards J. Early abortion: Surgical and medical options. Curr Probl Obstet Gynecol
Fertil 1997;20:1-32.
Creinin MD, Krohn MA. Methotrexate pharmacokinetics and effects in women receiving
methotrexate 50 mg and 60 mg per square meter for early abortion. Am J Obstet Gynecol
1997;177:1444-9.
Creinin MD, Shulman T. Effect of nonsteroidal anti-inflammatory drugs on the action of
misoprostol in a regimen for early abortion. Contraception 1997;56:165-8.
Creinin MD, Vittinghoff E. Methotrexate and misoprostol vs misoprostol alone for early
abortion. JAMA 1994;272:1190-5.
Creinin MD, Vittinghoff E, Galbraith S, Klaisle C. A randomized controlled trial comparing
misoprostol three and seven days following methotrexate for early abortion. Am J Obstet
Gynecol 1995;173:1578-84.
Creinin MD, Vittinghoff E, Keder L, Darney PD, Tiller G. Methotrexate and misoprostol for
early abortion: a multicenter trial. I. Safety and efficacy. Contraception 1996;53:321-7.
Creinin MD, Vittinghoff E, Schaff E, Klaisle C, Darney PD, Dean C. Medical abortion with
oral methotrexate and vaginal misoprostol. Obstet Gynecol 1997;90:611-6.
Crom WR, Taylor RH, Pratt CB. Methotrexate: therapeutic use and serum concentration
monitoring. In: Taylor WJ, Finn AL, editors. Individualizing Drug Therapy: Practical
Applications of Drug Monitoring. New York: Gross; Townsend, Frank, Inc. 1981. p.149-
73.
Darab DJ, Minkoff R, Sciote J, Sulik KK. Pathogenesis of median facial clefts in mice treated
with methotrexate. Teratology 1987;36:77-86.
DeLoia JA, Stewart-Akers AM, Creinin MD. Effects of methotrexate on trophoblast
proliferation and local immune responses. Hum Reprod 1998;13:1063-9.
Grimes DA. Medical abortion in early pregnancy: a review of the evidence. Obstet Gynecol
1997;89:790-6.